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Navigation Difficulties Could be Early Alzheimer’s Sign

businessman in the middle of a mazeScary news for those of us who have a difficult time figuring out where to go – this could be a very early sign of Alzheimer’s disease.

New research from a group at Washington University in St. Louis utilized computerized maze navigation to test those both with and without biomarkers for the disease.

The results led researchers to conclude that navigation difficulties do have a tie with disease risk.

Biomarkers for Alzheimer’s can be found by testing the brain and spinal fluids. These biomarkers can predict the development of the plaque that affects the hippocampus and caudate in the brain.

These areas of the brain are used for route learning, cognitive direction and map building. To measure the ability of these areas of the brain, a maze is sufficient.

These recent findings could allow health professionals to screen for and detect Alzheimer’s very early on and begin treating patients right away.

The study tested 42 clinically “normal” people with no biomarkers for Alzheimer’s, 13 with markers and 16 people with behavioral symptoms of early Alzheimer’s.

All participants were tested on their ability to navigate a virtual maze for town hours. There was an emphasis on seeing the users ability to learn and then follow a pre-set route. They were also tested on their ability to use a cognitive map.

Those with pre-clinical Alzheimer’s did worse than the normal group when it came to the tasks but they were able to overcome their issues and then preformed nearly on par with the normal group.

This could provide us with the incredibly valuable tool of early detection as we continue to move forward in search of a cure for the disease that impacts an estimated 5.4 million Americans.


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